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Never Use Alone

If you must use, call first. An operator stays on the line and sends help if you stop responding.

📞 1-800-484-3731

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Indiana Residents: Get No Cost Naloxone

Naloxone (Narcan) reverses opioid overdoses. Get it mailed to you at no cost - no questions asked.

📦 Get No Cost Naloxone

Find Harm Reduction Services in Indiana

Connecting you with life-saving harm reduction resources including needle exchanges, naloxone distribution, HIV testing, and more.

5,446

Agencies Listed

52

States & Territories

25

Service Types

Just want to understand harm reduction first? Start here →

Harm Reduction in Indiana

Indiana's syringe service programs trace back to a 2015 HIV outbreak in Scott County that pushed the legislature to authorize them for the first time. They remain legal today, but a law that took effect in March 2026 (Senate Enrolled Act 91, which became law without the governor's signature) added new requirements: participants must show ID proving county residency, programs must maintain a one-to-one syringe exchange, sites cannot operate within 1,000 feet of a school, child care center, or house of worship without written consent, and the authorization itself is only good for five more years. About six counties, including Clark County, currently run a program under this framework. Fentanyl test strips were decriminalized during the 2025 legislative session and are legal to possess statewide. Indiana's naloxone access runs through a statewide standing order renewed annually, and while the state does not have a stand-alone Good Samaritan law, its naloxone-access statute includes immunity for simple drug possession when someone acts in good faith to summon help.

Next Level Recovery, the state's umbrella opioid response initiative, coordinates prevention, treatment, and harm reduction efforts, and recently used SAMHSA grant funding to expand naloxone access across 62 rural counties. Naloxone is also available no-cost through vending machines and NaloxBoxes placed around the state.

Syringe services only operate in a handful of Indiana counties, and the new ID and residency requirements are recent. Confirm current rules with a local program before visiting.

Sources

Last reviewed September 2026 by Penny Beach, PRS.

How to Use Narcan (Naloxone) in Indiana

The Indiana Department of Health's "Naloxone 101" page explains how naloxone works and how to use it, and the department also offers a no-cost, self-paced online naloxone administration training open to the public.

Recognize the signs of an overdose — slow, shallow, or no breathing; blue or gray lips and fingertips; unresponsiveness; choking or gurgling sounds.
Call 911 immediately. Good Samaritan laws in most states protect both you and the person overdosing from drug-related charges when you call for help.
Give naloxone. For nasal spray, tilt the head back and insert the nozzle fully into one nostril, then press the plunger. For injectable naloxone, inject into the outer thigh muscle — it works through clothing.
Perform rescue breathing if you know how, and place the person in the recovery position (on their side) once breathing resumes on its own.
Stay until help arrives. If there's no response after 2–3 minutes, a second dose can be given. Naloxone wears off before most opioids do, so the person still needs emergency medical care.

Read Indiana's Naloxone 101 Guide →

These are general steps. Always follow the instructions included with your specific naloxone product.

Stay Safe Tips

Never Use Alone

Call 1-800-484-3731. They'll stay on the line and send help if needed.

Carry Naloxone

Get it no-cost from pharmacies and harm reduction agencies.

Test Your Supply

Use fentanyl test strips. One test could save your life.

Start Low, Go Slow

If you've taken a break, your tolerance is lower.

Use Clean Supplies

Never share needles, pipes, or straws.

You Are Worth It

Your life has value. We're here when you're ready.

Harm Reduction Agencies in Indiana

Recently added agencies in Indiana

Fire / EMS

City of Lawrence Fire Department Station 40, NaloxBox, free naloxone

9530 E 59th Street, Indianapolis, IN, 46216 Directions

Narcan/Naloxone

How to Access: A NaloxBox opioid rescue kit is mounted outside near the entrance. Overdose Lifeline says the boxes hold free naloxone nasal spray, are open to anyone 24 hours a day, need no appointment and need no contact with staff. Boxes are restocked regularly, so supply can run out.

View Details Last updated Sep 21, 2026

New Vista North, NaloxBox, free naloxone

4010 W. 86th Street Suite D, Indianapolis, IN, 46268 Directions

Narcan/Naloxone

How to Access: A NaloxBox opioid rescue kit is mounted outside near the entrance. Overdose Lifeline says the boxes hold free naloxone nasal spray, are open to anyone 24 hours a day, need no appointment and need no contact with staff. Boxes are restocked regularly, so supply can run out.

View Details Last updated Sep 21, 2026

Avenues Recovery Center at Indianapolis, NaloxBox, free naloxone

7960 Shadeland Ave, Indianapolis, IN, 46250 Directions

Narcan/Naloxone

How to Access: A NaloxBox opioid rescue kit is mounted outside near the entrance. Overdose Lifeline says the boxes hold free naloxone nasal spray, are open to anyone 24 hours a day, need no appointment and need no contact with staff. Boxes are restocked regularly, so supply can run out.

View Details Last updated Sep 21, 2026

Ascension St. Vincent Castleton, NaloxBox, free naloxone

8602 Allisonville Road, Indianapolis, IN, 46250 Directions

Narcan/Naloxone

How to Access: A NaloxBox opioid rescue kit is mounted outside near the entrance. Overdose Lifeline says the boxes hold free naloxone nasal spray, are open to anyone 24 hours a day, need no appointment and need no contact with staff. Boxes are restocked regularly, so supply can run out.

View Details Last updated Sep 21, 2026

Community Fairbanks Recovery Center, NaloxBox, free naloxone

8102 Clearvista Drive, Indianapolis, IN, 46256 Directions

Narcan/Naloxone

How to Access: A NaloxBox opioid rescue kit is mounted outside near the entrance. Overdose Lifeline says the boxes hold free naloxone nasal spray, are open to anyone 24 hours a day, need no appointment and need no contact with staff. Boxes are restocked regularly, so supply can run out.

View Details Last updated Sep 21, 2026

Fire / EMS

City of Lawrence Fire Department Station 37, NaloxBox, free naloxone

4902 N German Church Road, Indianapolis, IN, 46235 Directions

Narcan/Naloxone

How to Access: A NaloxBox opioid rescue kit is mounted outside near the entrance. Overdose Lifeline says the boxes hold free naloxone nasal spray, are open to anyone 24 hours a day, need no appointment and need no contact with staff. Boxes are restocked regularly, so supply can run out.

View Details Last updated Sep 21, 2026

Fire / EMS

City of Lawrence Fire Department Station 36, NaloxBox, free naloxone

7620 Oaklandon Road, Indianapolis, IN, 46236 Directions

Narcan/Naloxone

How to Access: A NaloxBox opioid rescue kit is mounted outside near the entrance. Overdose Lifeline says the boxes hold free naloxone nasal spray, are open to anyone 24 hours a day, need no appointment and need no contact with staff. Boxes are restocked regularly, so supply can run out.

View Details Last updated Sep 21, 2026

Community Health , Family and Internal Medicine Care, NaloxBox, free naloxone

5908 E Stop 11 Rd, Indianapolis, IN, 46237 Directions

Narcan/Naloxone

How to Access: A NaloxBox opioid rescue kit is mounted outside near the entrance. Overdose Lifeline says the boxes hold free naloxone nasal spray, are open to anyone 24 hours a day, need no appointment and need no contact with staff. Boxes are restocked regularly, so supply can run out.

View Details Last updated Sep 21, 2026

View All 237 Agencies in Indiana

Showing 8 recently added agencies in Indiana out of 237 total — search a city above to narrow it down

The Goals of Harm Reduction

Keep People Alive — Preventing overdose deaths through naloxone access, education, and never using alone.
Reduce Disease Transmission — Providing sterile syringes and equipment to prevent HIV, Hepatitis C, and bacterial infections.
Improve Quality of Life — Meeting people where they are with dignity, respect, and practical support.
Connect to Care — Building trust and providing pathways to treatment, housing, and healthcare when people are ready.
Reduce Stigma — Treating substance use disorder as a health issue, not a moral failing.
Empower Communities — Supporting people who use drugs to be active participants in their own health and safety.

Cities in Indiana

Local listings for these cities. The number is how many locations are listed.

9 cities

Harm Reduction Services

Find agencies that offer these critical services

Syringe Services

Safe syringe exchange programs that reduce disease transmission and provide a connection to care.

Naloxone Distribution

No Cost or low-cost naloxone (Narcan) distribution to reverse opioid overdoses.

HIV/HCV Testing

Confidential testing for HIV and Hepatitis C with connections to treatment.

Wound Care

Basic wound care services to prevent infections and complications.

Drug Checking

Fentanyl test strips and drug checking services to reduce overdose risk.

Browse by State

Find harm reduction agencies in your state. See the national overview

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What is Harm Reduction?

Harm reduction is a set of practical strategies and ideas aimed at reducing negative consequences associated with drug use. It is also a movement for social justice built on a belief in, and respect for, the rights of people who use drugs.

Meets people where they are without judgment
Reduces fatal overdoses through naloxone access
Prevents disease transmission through syringe services
Provides pathways to treatment when people are ready
Recognizes abstinence is not the only measure of success

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